Scientists make significant anti-ageing breakthrough

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Scientists at Newcastle University have identified that the activity of a key metabolic enzyme found in the batteries of human cells decline with age.


The discovery that the activity of mitochondrial complex II significantly decreases in older skin, brings experts a step closer to developing powerful anti-ageing treatments and cosmetic products which may be tailored to contract the decline in the activity levels.

Professor Mark Birch-Machin and Dr Amy Bowman who ran the study said “ As our bodies age we see that the batteries in our cells run down, known as decreased bio-energy, and harmful free radicals increase.”

phone battery

“This process is easily seen in our skin as increased fine lines, wrinkles and sagging appears” 

“Our study shows for the first time, in human skin that with increasing age there is a specific decrease in the activity of the key metabolic enzyme found in the batteries of the skin cells”

“This enzyme is the hinge between the two important ways of making energy in our cells and a decrease in its activity contributes to decreased bio-energy in ageing skin”

“Our research means that we now have a specific bio-marker, or a target, for developing and screening anti-ageing treatments and cosmetic creams that may counter this decline in bio-energy”

More research is required to fully understand the functional consequence in skin and other tissues, and to assess anti-ageing strategies in human skin.

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